Constitutively active calcineurin in skeletal muscle increases ...

Expression of an activated form of calcineurin in skeletal muscle selectively up-regulates slow-fiber-specific gene expression. Here, we tested the hypothesis that expression of activated calcineurin in skeletal muscle influences body ...

A Lethal Defect of Mitochondrial and Peroxisomal Fission — NEJM

We studied histologic and histochemical characteristics of a skeletal-muscle biopsy specimen using standard methods. Respiratory-chain enzymes were assayed in muscle homogenates as previous-ly described.6 Primary skin fibroblasts were cultured under standard ..... (2007) Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death. EMBO reports 8:10, 939-944. 31. Massimo Zeviani, Valerio Carelli. ...

Wnt11 patterns a myocardial electrical gradient through regulation ...

The calcineurin-mediated translocation is critically dependent on calcium entry through L- ... X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis o. Nature Jan 17, 2002 ... the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. Genetic defects in ClC Cl- channels underlie several familial . ...

Presence of SERCA and Calcineurin during Fetal Development of ...

Presence of SERCA and Calcineurin during Fetal Development of Porcine Skeletal Muscle. Henriëtte W. de Jonge, Cornelia W. van der Wiel, Karin Eizema, Wim A. Weijs and Maria E. Everts. Division of Anatomy and Physiology, Department of ...

Signaling Pathways for Cardiac Hypertrophy and Failure — NEJM

U Mende, A Kagen, A Cohen, J Aramburu, FJ Schoen, EJ NeerTransient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways.. Proc Natl Acad Sci U S A 1998;95:13893- ..... (2001) Skeletal muscle disorders in heart failure. Acta Physiologica Scandinavica 171:3, 277-294. 79. Annamaria Colao, Paolo Marzullo, Carolina Di Somma, Gaetano Lombardi. (2001) Growth hormone and the heart. ...